See What Is New In Dementia Research

Periodically I will search the web for newly publicized results of trials and will post them here. So far, no “magic bullets” have been discovered and many scientists are focusing on present healthy populations to see what lifestyle differences may benefit/protect the participants as they age.
It’s a multi-year study so we won’t be hearing what they have learned for a while!

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Biochemical Trigger Found May Be What Causes Alzheimer’s Disease

Scientists at the Instituto de Neurociencias de Alicante (Spain) reported some new findings in Alzheimer’s Research & Therapy. In Alzheimer’s Disease there are build-ups of two types of proteins in the brain: amyloid plaques and tau protein tangles. Beta-amyloid is a fragment of the larger protein called amyloid precursor protein (APP). When APP is broken down it either forms harmless proteins or the beta-amyloid during a process called glycosylation. The senior author, Javier Saez-Valero said this is dependent upon what sugar form is attached in the glycosylation process.

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The APOE4 Gene Disrupts Endocytosis, But The PICALM Gene Can Negate That Defect

Astrocytes help communication between neurons by maintaining the homeostasis for those cells. Those astrocytes that possess the APOE4 gene have impaired communication and are unable to maintain the metabolic needs of the cells they are supposed to help.

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